We identified miR-128 as a glioma tumor suppressor that targets RTK signaling to repress giNSC self-renewal and enhance differentiation. Using an autochthonous glioma mouse model, we demonstrated that miR-128 repressed gliomagenesis. miR-128 represses growth and mediates differentiation by targeting oncogenic receptor tyrosine kinases (RTKs) epithelial growth factor receptor and platelet-derived growth factor receptor-α. miR-128 represses giNSC growth by enhancing neuronal differentiation. With a combination of molecular, cellular and in vivo approaches, we characterize miR-128's tumor suppressive role. Decreased expression of miR-128 correlates with aggressive human glioma subtypes. We identified pro-neuronal miR-128 as a candidate glioma tumor suppressor miRNA. With the use of giNSCs and human glioblastoma cells, we investigated the function of miRNAs in gliomas. Gliomas are aggressive brain tumors that are thought to arise from transformed glioma-initiating neural stem cells (giNSCs). Aberrant expression of miRNA can lead to diseases, including cancer. MicroRNAs (miRNAs) carry out post-transcriptional control of a multitude of cellular processes. The development of this system, the GrapeIS, linking genotypes to phenotypes, and scientific research to agronomical and oeneological data, should provide new insights into grape biology, and allow the development of new varieties to meet the challenges of biotic and abiotic stress, environmental change, and consumer demand. To achieve this goal, it will be critical to develop, implement and adopt appropriate standards for data annotation and formatting. Considering the heterogeneous nature of the data produced, the transnational nature of the scientific community and the experience gained elsewhere, we have formed an open working group, in the framework of the International Grapevine Genome Program (to construct a coordinated federation of information systems holding grapevine data distributed around the world, providing an integrated set of interfaces supporting advanced data modeling, rich semantic integration and the next generation of data mining tools. Although the methods used in biology have evolved tremendously in recent years and now involve the routine production of large data sets of varied nature, in many domains of study, including grapevine research, there is a need to improve the findability, accessibility, interoperability and reusability (FAIR-ness) of these data. Viticulture, like other fields of agriculture, is currently facing important challenges that will be addressed only through sustained, dedicated and coordinated research. , Incontinência Urinária por Estresse/cirurgia LEVEL OF EVIDENCE: 4.Īssuntos Complicações Pós-Operatórias/cirurgia Post-operatively, half of the patients had SUI and a second MUS was a relevant treatment option after proper evaluation. Surgical treatment was associated with low morbidity in our study. CONCLUSION: Clinical presentation of MUS complications is heterogeneous.
Half of the patients with SUI after MUS section/removal were able to be treated by a second MUS with a success rate of 83 % at 3 years. At three months follow-up, 36 patients (53 %) had stress urinary incontinence (SUI), including 13 (19 %) de novo (meaning no SUI before MUS section/removal) and 19 (28 %) had overactive bladder, including 9 (13 %) de novo. Surgical management consisted in MUS partial removal (79 %) and MUS simple section (21 %) with low perioperative morbidity. This diagnosis delay was caused by a non-specific and heterogeneous symptomatology.
MUS complications surgically managed were vaginal mesh exposure (48 %), urethral mesh exposure (17 %), bladder mesh exposure (10 %) dysuria (30 %), pain (6 %), and infection (3 %). RESULTS: During this study, 96 patients were included. METHOD: Retrospective observational monocentric study of all patients treated by MUS section or removal, between December 2005 and October 2019, in a pelviperineology centre. OBJECTIVES: To identify various clinical presentation leading to the diagnosis of mid-urethral sling (MUS) complications and to analyze the functional outcomes after surgical management of these complications.
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